Pharmacological action of Aspirin Cardio manifested impact of acetylsalicylic acid (active substance) on the body. Aspirin Cardio refers to the group of nonsteroidal anti-inflammatory drugs .
Effect of Aspirin Cardio on the body due to the ability of blocking prostaglandinsynthase, an enzyme involved in the biosynthesis of prostaglandins. Inhibiting the production of hormones of inflammation (prostaglandin), Aspirin Cardio has analgesic, antipyretic, anti-inflammatory effect. Aspirin Cardio slows the aggregation (sticking together) and adhesion properties of platelets. This is due to the inhibition of biosynthesis of thromboxane A2 in platelets. After taking Aspirin Cardio, antiplatelet effect occurs within weeks (less pronounced in women than in men).
When exceeding daily dosage of Aspirin Cardio more than 6 g, observed in the inhibition of the biosynthesis of prothrombin in the hepatocytes, which in laboratory conditions, prolongs the prothrombin time.
Aspirin Cardio significantly increases the ability of blood plasma to fibrinolysis and reduces the specific amount of 10, 9, 7, 2 clotting factors, which are also called vitamin K-dependent. Analgesic effect is not expressed clearly, and due to lower susceptibility of nerve cells to the factors of irritation by reducing the total number of inflammatory mediators, which are the carriers of irritation.
Aspirin is rapidly and almost completely absorbed by ingestion. Food slows but does not reduce the absorption of Aspirin Cardio. Enteric-coated dosage forms drug prevents the release of acetylsalicylic acid in the stomach. This process occurs in the alkaline environment of the duodenum and small intestine. Therefore, Aspirin Cardio sucked for 2-5 h later, compared to conventional acetylsalicylic acid. Deacetylation 50% of acetylsalicylic acid occurs in hepatocytes, when passing from the intestine through the liver. The metabolic products of acetylsalicylic, salicylic acids are glycinate salicylic acid and gentisic acid glacincola. They are excreted by the kidneys in the form of metabolic products. The half-life is directly proportional to the quantity of acetylsalicylic acid and starts from 20 min after reaching maximum concentrations in plasma. In newborn infants the excretion of Aspirin occurs more slowly than in an adult organism. Aspirin Cardio easily penetrates natural barriers in the body. It is found in the cerebrospinal fluid, the joint cavity, fetal blood and in breast milk.
Indications for use of Aspirin Cardio apply to all diseases in which there is a risk or excessive clotting.
Cardio aspirin used as antiplatelet drug in the treatment of almost all forms of CHD, prevention of coronary heart disease (with risk factors), unstable and stable angina, myocardial infarction (prevention of thrombotic complications), operations on the heart and blood vessels.
In neurological practice for transient violations of cerebral circulation, cerebral ischemia. In cases of thrombophlebitis of lower limb veins (prevention of thromboembolism), recurrent pulmonary embolism, infarction of the lungs.
Aspirin Cardio take before meals, not liquid, squeezed enough liquid. Aspirin Cardio is one in 1-2 days. The treatment course is long, is set by the attending physician.
The usual dosage is 0.1 to 0.3 g/day. As a rule, first administered 0.3 g of Aspirin Cardio per day. After a therapeutic effect, confirmed by koagulogrammou, to supportive therapy – 0.1 g per day.
- Gastrointestinal tract. Marked pain, bloating, pain, spasmodic, disorders of the chair, a peptic ulcer (very rare), poor appetite, hepatitis, pancreatitis.
- Nervous system. Rarely observed symptoms of dizziness and headaches.
- Skin. Rare pruritus, urticaria, dermatitis, thrombocytopenic purpura.
- Urogenital system. Rarely, the symptoms of declining renal excretory function.
- Circulatory system. Rare anemia, leukopenia, eosinophilia, thrombocytopenia, agranulocytosis. When taking Aspirin Cardio there is an increased risk of bleeding, due to the offset of the coagulation-anticarcinoma of blood in the direction of anticoercive. Possible nasal, hemorrhoidal, esofagului, intestinal and other types of bleeding.
- Respiratory system. in observance of the contraindications are rare bronchospasm, laryngeal edema, cough.
In observance of the contraindications anaphylactic reactions are rare.
Individual intolerance of Aspirin Cardio and other NSAIDs, thrombocytopenia, and aspirin asthma triad of coagulopathy (hemophilia, hemorrhagic diathesis, and others), thrombocytopenic purpura, gastric ulcer, duodenal ulcer (acute or bleeding), portal cirrhosis of the liver, 1 and 3 trimesters of pregnancy, lactation, failure of the liver and kidney, age younger than 15 years.
With caution used Aspirin Cardio in patients, patients with urolithiasis, bronchial asthma, alcoholism, gout, hepatitis, hyperuricemia, peptic ulcer disease of stomach and duodenal ulcers (in remission), in the 2nd trimester of pregnancy.
Pregnancy and Aspirin Cardio:
It is better to refrain from taking Aspirin Cardio during pregnancy since it readily crosses the placental barrier. In 1 and 3 trimester contraindications categorical. In term 2, you should match the value of the expected therapeutic effect with risk of fetal malformations of the fetus.
Lactation Aspirin Cardio contraindicated.
Interaction with other medicines:
Not recommended simultaneous with the appointment of Aspirin Cardio and other medications with salicylic acid as it causes potentiation of side effects and reduction of therapeutic efficacy. Joint appointment with the direct anticoagulants (heparin) and indirect effect, increases the risk of hemorrhage.
Aspirin Cardio increases the number of lithium ions in the blood, while treatment with metal salts. After 2-3 days, when co-administered with digoxin, increasing the level of glycoside in the plasma. After discontinuation of Aspirin Cardio concentration of digoxin in the blood will normalize no earlier than 48 hours.
Aspirin Cardio helps delay sodium and water in the body, reducing the therapeutic effect of diuretics and antihypertensives. Co-administration with antibiotics ziklosporinom series enhances the nephrotoxic effect.
Corticosteroids enhance the toxicity of Aspirin Cardio. Between methotrexate and Aspirin Cardio needed a break for 24 hours, to avoid toxicity of the drug.
Overdose of Aspirin Cardio:
There are three degrees of severity of overdose.
The first degree occurs when a single dose of Aspirin Cardio less than 0.15 g/kg body weight of the patient. Symptoms: dyspepsia, headache, disorders of vision, fever. Second degree occurs when a single dose of Aspirin Cardio from 0.15 to 0.3 g/kg body weight of the patient, a third in the case of more than 0.3 g/kg.
If poisoning is used gastric lavage and oral adsorbents, laxatives, symptomatic treatment. It is necessary to control the pH of blood and the introduction of sodium bicarbonate in cases of shifting of homeostasis in the acid side. Hemodialysis and mechanical ventilation is used in severe cases, according to testimony.
- Tablets, enteric coated 0.1 grams.
- Tablets, enteric coated 0.3 grams
- Aspirin Cardio is kept at a temperature not exceeding 25 degrees Celsius in a place inaccessible to children.
Structure of Aspirin Cardio:
One tablet Aspirin Cardio contains acetylsalicylic acid (active substance) 0.1 or 0.3 g.
Excipients: talc, corn starch, cellulose, copolymer of methacrylic acid and ethyl ester of acrylic acid, sodium lauryl sulfate, Polysorbate 80, triethylcitrate.
Active substance: Aspirin
Additional information about Aspirin Cardio:
During treatment with Aspirin Cardio in patients with chronic liver diseases and kidney, recommended laboratory control functions of these bodies. Monitoring of coagulation parameters were shown in cases of violation of the coagulation-anticoercive of the blood system. Testing of stool for the presence of occult blood is carried out for patients who have a history of ulcerative lesions of the stomach and duodenum.
The course of treatment Aspirin Cardio long. Doctor set the dosage and duration of application. You should not take Aspirin Cardio alone. Activity of Aspirin Cardio persists for several days after discontinuation of the drug that must be considered when surgical treatment. The elderly are most sensitive to a drug overdose.
Aspirin Cardio does not affect concentration and attention.