Infectious diseases

Brill’s zinsser disease

Brill’s Disease – remote endogenous relapse of typhus, characterized by sporadically in the absence of head lice.

Striking in a few years recovered after suffering typhoid persons during their stay in the countries where this disease is present.


Pathogen — Rickettsia of Prowazek probably the part had been ill with typhus long-term remains in the body. However, the causes of relapse in the long term is unknown.

Symptoms of Brill’s disease

Brill’s Disease differs from typhus more mild current, moderate temperature reactions (sometimes low-grade fever) with a shortened period of fever. Also, as in typhus fever, exanthema develops to 5-6-th day of illness, however, the number of elements is smaller, the rash can only be roseolous, without petechiae. In some cases, the rash persists for only 1-2 days.

Diagnostics and treatment of Brill’s disease

Great value for a confident diagnosis are the reactions of binding of the specific complex, microscopic agglutination and immunofluorescence antibodies. When illness Brill complementative specific antibodies appear 4 days after the onset of the disease; antibodies belong to the IgG class, and their peak concentration is reached at 8-10 days of disease. The titers of specific antibodies in the primary attack of epidemic typhus are defined later, at approximately 8-12 days of illness, and the maximum titer is reached in about 16 days after the onset of the disease.

Assign tetracycline 0.3 – 0.4 g after 6 h for 4-5 days. Indications for use symptomatic and pathogenic agents.

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